FPH1 (BRD-6125) (Synonyms: FPH1) |
| Catalog No.GC14922 |
FPH1(BRD-6125)(BRD-6125)은 시험관 내에서 1차 인간 간세포의 수와 활성을 증가시키고 간 계통으로 iPS 세포의 분화를 촉진합니다.
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Cas No.: 708219-39-0
Sample solution is provided at 25 µL, 10mM.
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FPH1 is a small molecule that promotes the functional proliferation of primary hepatocytes [1].
FPH1 belongs to the functional proliferation hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. This ability of FPH1 is not dependent on the donors of the hepatocytes. It has been found that FPH1 was active against the primary human hepatocytes from six cell sources of genetically diverse individuals. Besides that, FPH1 can affect the hepatocyte functions with promoting albumin secretion during the differentiation of iPS cells into iHeps. Moreover, treatment of FPH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion [1].
References:
[1] Shan J, Schwartz R E, Ross N T, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology, 2013.
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