Cardiotoxin Analog (CTX) IV 6-12 |
Catalog No.GC35609
One-Click Copy Product Info
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Cardiotoxin Analog (CTX) IV 6-12는 사이클로포스파미드 유사물 (CTX) IV의 펩타이드 조각으로 블랙 나자아트라의 독액에서 유래되어 독특한 심장 독소 유사물이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 115722-23-1
Sample solution is provided at 25 µL, 10mM.
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Cardiotoxin Analog (CTX) IV 6-12는 사이클로포스파미드 유사물 (CTX) IV의 펩타이드 조각으로 블랙 나자아트라의 독액에서 유래되어 독특한 심장 독소 유사물이다. Cardiotoxin Analog (CTX) IV 6-12는 신경 독소와 무스카린 독소와 비슷한 세 손가락 고리 구조를 가지고 있고 많은 세포에 대한 세포용해 효과를 가진다[2]. Cardiotoxin Analog (CTX) IV 6-12는 순탄하고 뼈 속 근육의 극화와 수축을 일으키고 신경 세포의 극화도 유도한다[3]. Cardiotoxin Analog (CTX) IV 6-12는 카르돈리핀이나 스핑고마이닌과 같은 인지질로 형성된 포도당의 촉합을 유도할 수 있다[4]. Cardiotoxin Analog (CTX) IV 6-12는 지금까지 알려진 유일한 심장 독소 이소형으로 N말단 아미노산에 양전하를 가진 잔존이 있다[5]. CTX IV는 CTX II와의 차이점은 CTX IV가 위치 1에 아르기닌 대신 르시닌 잔존이 포함되어 있다는 것이다[6].
References:
[1] Kaneda N, Sasaki T, Hayashi K. Primary structures of cardiotoxin analogues II and IV from the venom of Naja naja atra[J]. Biochimica et Biophysica Acta (BBA)-Protein Structure, 1977, 491(1): 53-66.
[2] Wu W G. Diversity of cobra cardiotoxin[J]. Journal of Toxicology: Toxin Reviews, 1997, 16(3): 115-134.
[3] Harvey A L. Cardiotoxins from cobra venoms: possible mechanisms of action[J]. Journal of Toxicology: Toxin Reviews, 1985, 4(1): 41-69.
[4] Forouhar F, Huang W N, Liu J H, et al. Structural basis of membrane-induced cardiotoxin A3 oligomerization[J]. Journal of Biological Chemistry, 2003, 278(24): 21980-21988.
[5] Jang J Y, Kumar T K S, Jayaraman G, et al. Comparison of the hemolytic activity and solution structures of two snake venom cardiotoxin analogues which only differ in their N-terminal amino acid[J]. Biochemistry, 1997, 36(48): 14635-14641.
[6] Kumar T K S, Pandian S T K, Jayaraman G, et al. Understanding the structure, function and folding of cobra toxins[J]. PROCEEDINGS-NATIONAL SCIENCE COUNCIL REPUBLIC OF CHINA PART A PHYSICAL SCIENCE AND ENGINEERING, 1999, 23: 1-19.
| Cas No. | 115722-23-1 | SDF | |
| Formula | C48H70N10O7 | M.Wt | 899.13 |
| Solubility | 100 mg/ml in water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1122 mL | 5.5609 mL | 11.1219 mL |
| 5 mM | 222.4 μL | 1.1122 mL | 2.2244 mL |
| 10 mM | 111.2 μL | 556.1 μL | 1.1122 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)