Gemcabene (Synonyms: PD-72953) |
| Catalog No.GC36128 |
젬카벤(PD-72953)은 동급최초 지질저하제로서 저밀도지단백콜레스테롤(LDL-C)을 낮추고 중성지방을 감소시키며 고밀도지단백콜레스테롤(HDL-C)을 높이고 염증유발을 감소시킨다. 급성기 단백질, C-반응성 단백질(CRP), 항염증 활성.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 183293-82-5
Sample solution is provided at 25 µL, 10mM.
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Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].
Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2)[3].
[1]. Mandema JW, et al. Model-based development of gemcabene, a new lipid-altering agent. AAPS J. 2005 Oct 7;7(3):E513-22. [2]. Srivastava RAK, et al. Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain. Front Pharmacol. 2018 May 11;9:471. [3]. Oniciu DC, et al. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. PLoS One. 2018 May 30;13(5):e0194568.
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