Methylnissolin (Synonyms: (–)-Methylnissolin) |
| Catalog No.GC36596 |
황기에서 분리된 메틸니솔린(Astragalus membranaceus)은 10μM의 IC50으로 혈소판 유래 성장 인자(PDGF)-BB 유도 세포 증식을 억제합니다.
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Cas No.: 73340-41-7
Sample solution is provided at 25 µL, 10mM.
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Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1]. PDGFR|10 μM (IC50)|ERK1 ERK2
[1]. Ohkawara S, et al. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2005 Nov 21;525(1-3):41-7.
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