ORM-10962 |
| Catalog No.GC36815 |
ORM-10962는 역방향 및 순방향 모드 억제에 대해 IC50 값이 각각 67 및 55nM인 강력하고 선택성이 높은 NCX(나트륨-칼슘 교환체) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 763926-98-3
Sample solution is provided at 25 µL, 10mM.
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ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively[1][2]. NCX[1][2].
[1]. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041. [2]. Oravecz K, et al. Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. Eur J Pharmacol. 2018 Jan 5;818:278-286.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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