GnRH II (trifluoroacetate salt) (Synonyms: Gonadotropin-releasing Hormone II, LHRH II) |
| Catalog No.GC43782 |
Gonadotropin-releasing hormone II (GnRH II) is a peptide agonist of the GnRH receptor (GnRHR).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Gonadotropin-releasing hormone II (GnRH II) is a peptide agonist of the GnRH receptor (GnRHR). It binds to human recombinant type I and marmoset type II GnRHRs (IC50s = 26.1 and 1.07 nM, respectively, in COS-7 cells) and stimulates inositol phosphate production (EC50s = 7.41 and 0.45 nM, respectively). GnRH II stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from cultured primary rhesus monkey anterior pituitary cells (EC50s = 0.37 and 0.59 nM, respectively) and dose-dependently stimulates LH and FSH release from cultured primary rat anterior pituitary cells. In vivo, GnRH II (1 μg/kg, i.v.) increases plasma LH levels in White Leghorn pullets but does not affect plasma FSH levels. It also decreases food intake in zebrafish and increases courtship behavior in female white-crowned sparrows when administered intracerebroventricularly at doses of 1 pmol/g and 100 ng, respectively.
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