HeE1-2Tyr |
| Catalog No.GC63500 |
피리도벤조티아졸 화합물인 HeE1-2Tyr은 플라비바이러스 RNA 의존성 RNA 중합효소(RdRp) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2245195-67-7
Sample solution is provided at 25 µL, 10mM.
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HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro[1][2].
HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 µM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 µM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 µM[1].Additionally, upon infection of human HEK 293 cells (CC50 of 50 µM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 µM[1]. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)[2].
[1]. Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235.
[2]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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