Lapaquistat acetate (Synonyms: TAK-475) |
| Catalog No.GC38807 |
Lapaquistat acetate(TAK-475)는 콜레스테롤 생합성 경로에서 파르네실 이인산(FPP)이 스쿠알렌으로 전환되는 것을 차단하는 스쿠알렌 합성 효소 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 189060-13-7
Sample solution is provided at 25 µL, 10mM.
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Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene[1]. Lapaquistat acetate (TAK-475) is originally intended use to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage[2].
[1]. Stein EA, et al. Lapaquistat acetate: development of a squalene synthase inhibitor for the treatment of hypercholesterolemia. Circulation. 2011 May 10;123(18):1974-85. [2]. Marcuzzi A, et al. Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice. Curr Med Chem. 2018;25(24):2783-2796.
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