Lipid C3 (Synonyms: C16-6) |
Catalog No.GC91597
One-Click Copy Product Info
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Lipid C3 is an ionizable cationic lipid (pKa = 5.05-5.671).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2639634-93-6
Sample solution is provided at 25 µL, 10mM.
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Lipid C3 is an ionizable cationic lipid (pKa = 5.05-5.671).[1],[2] It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.[1] Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating mRNA encoding α-L-iduronidase (Idua) to neonates increase midbrain and hippocampal α-L-iduronidase enzyme activity and decrease forebrain, midbrain, and hippocampal glycosaminoglycan levels in an Idua-W392X mouse model of the lysosomal storage disorder mucopolysaccharidosis type I, also known as Hurler syndrome. Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating an mRNA reporter to fetal macaques in utero increase brain GFP expression.
References:
[1].Palanki, R., Bose, S.K., Dave, A., et al.Ionizable lipid nanoparticles for therapeutic base editing of congenital brain disease.ACS Nano17(14)13594-13610(2023).
[2].Billingsley, M.M., Singh, N., Ravikumar, P., et al.Ionizable lipid nanoparticle-mediated mRNA delivery for human car T cell engineeringNano Lett.20(3)1578-1589(2020).
| Cas No. | 2639634-93-6 | SDF | |
| Synonyms | C16-6 | ||
| Formula | C96H197N5O7 | M.Wt | 1533.6 |
| Solubility | Chloroform: Soluble,Ethanol: Soluble,Methanol: Soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 652.1 μL | 3.2603 mL | 6.5206 mL |
| 5 mM | 130.4 μL | 652.1 μL | 1.3041 mL |
| 10 mM | 65.2 μL | 326 μL | 652.1 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)