LTA4H-IN-1 |
| Catalog No.GC63435 |
LTA4H-IN-1은 특허 WO2015092740A1(실시예 29)에서 추출한 류코트리엔 A4 가수분해효소(LTA4H)의 강력한 억제제이며 IC50이 2nM입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1799681-85-8
Sample solution is provided at 25 µL, 10mM.
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LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders[1].
LTA4H-IN-1 (15 min) inhibits the hydrolysis of 7-amino-4-methylcoumarin (AMC) derivative of Arginine (Arg-AMC) which is catalyzed by LTA4H, with an IC50 of 2 nM[1].LTA4H-IN-1 (30 min) inhibits LTB4 biosynthesis in a human whole blood assay (hWB), with an IC50 of 167 nM[1].
LTA4H-IN-1 (0.3 mg/kg; a single p.o.) inhibits the -43% release of LTB4 compared with vehicle control in mice[1].
[1]. Bollbuck B, et, al. Heteroaryl butanoic acid derivatives as leukotriene A4 hydrolase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO2015092740A1.
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