LysRs-IN-2 |
| Catalog No.GC65058 |
LysRs-IN-2는 Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) 및 Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS)에 대한 IC50가 각각 0.015 μM 및 0.13 μM인 lysyl-tRNA 합성효소(KRS) 억제제입니다.
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Cas No.: 2170696-76-9
Sample solution is provided at 25 µL, 10mM.
LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS), respectively[1].
LysRs-IN-2 is active against whole-cell bloodstream P. falciparum 3D7 (EC50=0.27 μM), HsKRS (IC50=1.8 μM), HepG2 cells (EC50=49 μM), and Cryptosporidium parvum (EC50=2.5 µM)[1].
LysRs-IN-2 (1.5 mg/kg; orally once a day for 4 days) reduces parasitemia by 90% in the murine P. falciparum SCID model. LysRs-IN-2 (20 mg/kg; orally once a day for 7 days) reduces parasite shedding in NOD SCID gamma mice and INF-γ-knockout mice (Cryptosporidium mouse models)[1].
[1]. BaragaÑa B, et al. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020.
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