MAC glucuronide phenol-linked SN-38 |
| Catalog No.GC39401 |
MAC 글루쿠로나이드 페놀-연결된 SN-38은 pH에 민감한 락톤 MAC 글루쿠로나이드 페놀-연결된 SN-38(DNA 토포이소머라제 I 억제제) 약물 링커입니다. MAC 글루쿠로나이드 페놀-연결 SN-38은 각각 113 및 67ng/mL의 IC50 값으로 L540cy 세포 및 라모스 세포에 걸쳐 세포독성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2246380-69-6
Sample solution is provided at 25 µL, 10mM.
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MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively[1].
[1]. Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072.
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