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Manganese(salen) chloride

Catalog No.GC61930

망간(살렌) 염화물(EUK-8), 슈퍼옥사이드 디스뮤타제 및 카탈라제 모방체는 옥시라디칼 소거 특성이 있는 항산화제입니다.

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Manganese(salen) chloride Chemical Structure

Cas No.: 53177-12-1

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$49.50
재고 있음
10 mg
US$45.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].

Manganese(salen) chloride (25 µM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2].

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3].

References:
[1]. Gonzalez PK, et, al. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov;275(2):798-806.
[2]. Bruce AJ, et, al. beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2312-6.
[3]. Empel VPM, et, al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006 Aug 15;48(4):824-32.

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