MC-Val-Cit-PAB-MMAF (Synonyms: Vc-MMAF) |
| Catalog No.GC61035 |
MC-Val-Cit-PAB-MMAF(Vc-MMAF)는 카텝신 절단 가능한 MC-Val-Cit-PAB를 통해 연결된 튜불린 억제제인 MMAF를 사용하여 ADC에 대한 약물-링커 접합체입니다. MC-Val-Cit-PAB-MMAF는 항종양 활성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 863971-17-9
Sample solution is provided at 25 µL, 10mM.
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MC-Val-Cit-PAB-MMAF is a drug-linker conjugate for ADC with antitumor activity by using the tubulin inhibitor, MMAF, linked via cathepsin cleavable MC-Val-Cit-PAB.
[1]. Cheng X, et al. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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