ML-179 (Synonyms: CID45100448) |
| Catalog No.GC44215 |
ML-179(SR-1309)는 320nM의 IC50을 갖는 역 LRH1(간 수용체 동족체-1) 작용제입니다. ML-179는 MDA-MB-231 세포에서 항증식 활성을 나타냅니다. ML-179는 ER-음성 유방암 연구에 대한 잠재력이 있습니다.
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Cas No.: 1883548-87-5
Sample solution is provided at 25 µL, 10mM.
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ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.12 µM).
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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