Nitracrine |
| Catalog No.GC33400 |
니트라크린은 RNA 합성을 억제하고 공유적으로 DNA에 가역적으로 결합하지만 생체 내에서 DNA와 공유 부가물을 형성하기도 합니다. 1-nitroacridine 유도체인 Nitracrine은 시험관 내 및 항종양 약물에 대한 강력한 저산소증 선택제입니다. 니트라크린은 대부분의 세포에 대해 세포독성을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4533-39-5
Sample solution is provided at 25 µL, 10mM.
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Nitracrine is an antitumor drug that has been used clinically for several years.
It is demonstrated during the reduction of ledakrin that a key metabolite, a compound with anadditional five-membered ring attaching to positions 1 and 9 of the acridine core and with the retained 9-aminoalkyl side chain, is formed in all the systems that are studied. It is determined that the reactive nitrogen atoms of this additional ring undergo further transformations resulting in the formation of a six-membered ring produced by the addition of a carbon atom to the dihydropyrazoloacridine ring. Furthermore, it is observed that positions 2 and 4 of ledakrin's acridine ring are susceptible to nucleophilic substitution as revealing by the studies with dithiothreitol. Additionally, although most products from the reduction of ledakrin are extremely unstable, 1-aminoacridinone, producing enzymatically and with dithiothreitol, exhibiting persistent stability under the studied conditions[1].
[1]. Gorlewska K, et al. Products of metabolic activation of the antitumor drug ledakrin (nitracrine) in vitro.
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