Oxyphenisatin acetate |
| Catalog No.GC33446 |
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Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 115-33-3
Sample solution is provided at 25 µL, 10mM.
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Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative.
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction[1].
Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model[1].
[1]. Morrison BL, et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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