Pancreatic Polypeptide, rat (Rat pancreatic polypeptide) (Synonyms: Rat pancreatic polypeptide) |
Catalog No.GC33785 |
췌장 폴리펩티드, 쥐(쥐 췌장 폴리펩티드)는 NPYR4에서 높은 친화성을 갖는 NPY 수용체의 작용제입니다.
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Cas No.: 90419-12-8
Sample solution is provided at 25 µL, 10mM.
Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4.
Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca2+)i levels in BRIN BD11 cells at 1 μM[1].
Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice[1].
[1]. Khan D, et al. Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. Biochim Biophys Acta. 2017 Apr;1861(4):749-758.
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