PD 404182 |
| Catalog No.GC50104 |
PD 404182는 IC50이 9μM인 인간 디메틸아르기닌 디메틸아미노하이드롤라제 1(DDAH1)의 강력하고 경쟁적인 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72596-74-8
Sample solution is provided at 25 µL, 10mM.
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High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.
Birck et al (2000) Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J.Am.Chem.Soc. 122 9334 |Ghebremariam et al (2013) A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J.Pharmacol.Exp.Ther. 348 69 PMID:24135074 |Chamoun-Emanuelli et al (2014) Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob.Agents Chemother. 58 687 PMID:24217696
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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