PDD 00017272 |
| Catalog No.GC50637 |
PDD 00017272(34f)는 생화학적 분석 및 세포 POM에서 각각 4.8 nM 및 9.2 nM의 EC50을 갖는 폴리(ADP-리보스) 당가수분해효소(PARG)의 강력한 억제제입니다.
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Cas No.: 1945950-20-8
Sample solution is provided at 25 µL, 10mM.
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Potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).
Waszkowycz et al (2018) Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem. 61 10767 PMID:30403352
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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