PGD2-IN-1 |
| Catalog No.GC31778 |
PGD2-IN-1은 특허 WO 2006044732 A2, 실시예 15(d)에서 추출한 DP의 길항제이고; IC50은 0.3nM입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 885066-67-1
Sample solution is provided at 25 µL, 10mM.
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PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.
Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonistshave been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically have been shown to inhibit the antigen-induced nasal congestion[1].
[1]. Patent: WO/2006/044732A2 [2]. Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75.
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