Phosphatidic Acids (ammonium salt) |
Catalog No.GC91806
One-Click Copy Product Info
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Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis.[1] It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple routes, including the glycerol-3 phosphate and dihydroxyacetone phosphate pathways, enzymatic conversion of phosphatidylcholine by phospholipase D, and acetylation of lysophosphatidic acid by lysoPA-acyltransferase, among others.2,3 It has roles in shaping cellular membranes, cellular signaling, vesicle fission and fusion, as well as mitochondrial division and fusion. It stimulates respiratory burst in neutrophils independent of diacylglycerol and activates monoacylglycerol acyltransferase, phospholipase C (PLC), Ras, and phosphatidylinositol 4-phosphate (PIP4) kinase in several cell lines. This product contains phosphatidic acid molecular species with primarily C16:0 and C18:1 fatty acyl chain lengths.
References:
[1].Athenstaedt, K., and Daum, G.Phosphatidic acid, a key intermediate in lipid metabolismEur. J. Biochem.266(1)1-16(1999).
[2].Járai, Z., Wagner, J.A., Goparaju, S.K., et al.Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized miceHypertension35679-684(2000).
[3].Kameoka, S., Adachi, Y., Okamoto, K., et al.Phosphatidic acid and cardiolipin coordinate mitochondrial dynamicsTrends Cell Biol.28(1)67-76(2018).
| Cas No. | N/A | SDF | |
| Formula | C39H72O8P•NH4 (for oleoyl) | M.Wt | 718 |
| Solubility | Chloroform: soluble,Ether: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3928 mL | 6.9638 mL | 13.9276 mL |
| 5 mM | 278.6 μL | 1.3928 mL | 2.7855 mL |
| 10 mM | 139.3 μL | 696.4 μL | 1.3928 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)