Pioglitazone (potassium salt) (Synonyms: U 72107 potassium) |
| Catalog No.GC44645 |
피오글리타존(U 72107) 칼륨은 경구 활성 및 선택적 PPARγ입니다. PPAR⋳에 대한 높은 친화도 결합을 갖는 (퍼옥시좀 증식제-활성화 수용체) 작용제; EC50이 0.93 μ인 리간드 결합 도메인, M 및 0.99 μ, M, 인간 및 마우스 PPARγ, 각각.
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Cas No.: 1266523-09-4
Sample solution is provided at 25 µL, 10mM.
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Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ). It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM. Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM. In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats. It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model. Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 .
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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