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Pomaglumetad methionil hydrochloride (Synonyms: LY2140023 hydrochloride)

Catalog No.GC63150

포마글루메타드 메티오닐 염산염(LY2140023 염산염)은 선택적 mGlu2/3 수용체 작용제 LY404039의 경구 활성 메티오닌 전구약물입니다.

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Pomaglumetad methionil hydrochloride Chemical Structure

Cas No.: 635318-26-2

Size 가격 재고 수량
5 mg
US$585.00
재고 있음
10 mg
US$1,035.00
재고 있음
25 mg
US$2,205.00
재고 있음
50 mg
US$3,465.00
재고 있음
100 mg
US$5,265.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research[1][2].

Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 µM[2].LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].

Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1].

[1]. Lowe S, et al. Effects of a novel mGlu?/? receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70.
[2]. Y Anne Pak, et al. In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1. Drug Metab Dispos. 2017 Feb;45(2):137-144.

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