Prostaglandin A2 methyl ester (Synonyms: Medullin methyl ester, PGA2 methyl ester) |
| Catalog No.GC44704 |
Prostaglandin A2 (PGA2) is a naturally occurring PG in gorgonian corals where it may function in self defense.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 31753-19-2
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin A2 (PGA2) is a naturally occurring PG in gorgonian corals where it may function in self defense. At a 25 µM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at G1 and G2/M by preventing activation of cyclin-dependent kinases. At similar concentrations, it stabilizes transcripts for the tumor suppressor SMAR1, downregulating cyclin D1 expression. PGA2 also induces apoptosis in HL-60 cells. Prostaglandin A2 methyl ester is a lipophilic analog of PGA2 which may be more amenable for certain formulations or applications. Its biological properties have not been evaluated.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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