PROTAC FLT-3 degrader 1 |
| Catalog No.GC65555 |
PROTAC FLT-3 분해제 1은 IC50 값이 0.6 nM인 폰 히펠-린다우 기반의 PROTAC FLT-3 내부 이중 복제 (ITD) 분해제입니다. 항 증식 활성 및 세포 자살 유도 작용이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2230826-81-8
Sample solution is provided at 25 µL, 10mM.
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PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1].
[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.
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