Quercetin D5 |
Catalog No.GC61227
One-Click Copy Product Info
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Quercetin D5는 천연 화합물 케르세틴의 중수소 대체 내부 기준이고 그 화학 구조는 케르세틴과 기본적으로 같지만 A환의 5개 수소(H) 원자가 5개 중수소(D) 원자로 대체된다는 점이 다르다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 263711-78-0
Sample solution is provided at 25 µL, 10mM.
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Quercetin D5는 천연 화합물 케르세틴의 중수소 대체 내부 기준이고 그 화학 구조는 케르세틴과 기본적으로 같지만 A환의 5개 수소(H) 원자가 5개 중수소(D) 원자로 대체된다는 점이 다르다. Quercetin D5와 천연 케르세틴의 특이적질량 분광학 이온쌍을 관찰하고 그 반응비를 계산해서 매우 정밀하고 정확한 표준곡선을 구축할 수 있고 생물학적 시료에서 매우 낮은 농도(나노그램/mL 수준)의 케르세틴의 절대정량이 가능하다[2, 3].
Quercetin D5를 내부 기준으로 사용하면 경구 투여 후 흰쥐의 혈장과 조직에서 케르세틴의 농도를 정확하게 측정할 수 있고 신뢰할 수 있는 약동학적 매개변수를 계산할 수 있다[4]. 케르세틴은 항염증, 항알레르기, 항바이러스, 심혈관계 보호 및 항암 활성 등 다양한 연구 분야에서 응용되는 천연 플라보노이드 화합물이다[5].
References:
[1] Rasku S, Wähälä K. Synthesis of deuterium labeled polyhydroxy flavones and 3-flavonols[J]. Tetrahedron, 2000, 56(6): 913-916.
[2] Ma L, Peng Y, Cao D, et al. Difference Analysis of Non-Volatile and Volatile Components in Kujingcha (Ilex dabieshanensis) Compared with Green Tea (Camellia sinensis)[J]. Horticulturae, 2025, 11(7): 804.
[3] Wolfender J L. HPLC in natural product analysis: the detection issue[J]. Planta medica, 2009, 75(07): 719-734.
[4] Pilařová V, Plachká K, Chrenková L, et al. Simultaneous determination of quercetin and its metabolites in rat plasma by using ultra-high performance liquid chromatography tandem mass spectrometry[J]. Talanta, 2018, 185: 71-79.
[5] Aghababaei F, Hadidi M. Recent advances in potential health benefits of quercetin[J]. Pharmaceuticals, 2023, 16(7): 1020.
| Cas No. | 263711-78-0 | SDF | |
| Canonical SMILES | O=C1C(O)=C(C2=C([2H])C(O)=C(O)C([2H])=C2[2H])OC3=C([2H])C(O)=C([2H])C(O)=C13 | ||
| Formula | C15H5D5O7 | M.Wt | 307.27 |
| Solubility | Storage | Store at 2-8°C,protect from light | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2545 mL | 16.2723 mL | 32.5447 mL |
| 5 mM | 650.9 μL | 3.2545 mL | 6.5089 mL |
| 10 mM | 325.4 μL | 1.6272 mL | 3.2545 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)