Rimacalib (SMP 114) (Synonyms: SMP 114) |
| Catalog No.GC33775 |
리마칼리브(SMP 114)(SMP 114)는 ~1 μ의 IC50을 갖는 Ca2+/칼모듈린 의존성 단백질 키나제 II(CaMKII) 억제제입니다. ~ 30 μ CaMKIIγ의 경우 M;.
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Cas No.: 215174-50-8
Sample solution is provided at 25 µL, 10mM.
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Rimacalib is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC50s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ.
Rimacalib (SMP-114) improves (by ~40%) Ca2+-transient potentiation during the 30 s stimulation pause, higher Fura-2 transient amplitude after the pause upon Rimacalib vs. 37.2±4.3% in control, n=60/17 cells/mice vs. n=65/17, p<0.05) and in parallel cardiomyocyte contractility (135.0±15.4% vs. 97.2±16% increase of twitch amplitude, p=0.098)[1].
[1]. Neef S, et al. Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability. Basic Res Cardiol. 2017 Jul;112(4):45.
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