Spirapril hydrochloride |
| Catalog No.GC64597 |
스피라프릴(SCH 33844) 염산염은 항고혈압 활성이 있는 강력한 안지오텐신 전환 효소(ACE) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 94841-17-5
Sample solution is provided at 25 µL, 10mM.
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Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1].
Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.[2]
[1]. Spirapril. Drugbank.
[2]. B Maul, et al. Alcohol consumption is controlled by angiotensin II. FASEB J
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