SPP-86 |
| Catalog No.GC34809 |
SPP-86은 IC50이 8nM인 RET 티로신 키나제의 강력하고 선택적인 세포 투과성 억제제입니다. SPP-86은 RET 유도 포스파티딜이노시티드 3-키나제(PI3K)/Akt 및 MAPK 신호 전달을 억제하고 MCF7 세포에서 RET 유도 에스트로겐 수용체α(ERα) 인산화도 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1357349-91-7
Sample solution is provided at 25 µL, 10mM.
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SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 selectively inhibits RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines[1]. IC50: 8 nM (RET)[1].
[1]. Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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