Thalidomide-NH-CH2-COOH |
| Catalog No.GC62378 |
탈리도마이드-NH-CH2-COOH는 CRBN 단백질 모집에 사용되는 탈리도마이드 기반 세레블론 리간드입니다. 탈리도마이드-NH-CH2-COOH는 링커에 의해 단백질에 대한 리간드에 연결되어 THAL-SNS-032와 같은 PROTAC를 형성할 수 있습니다.
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Cas No.: 927670-97-1
Sample solution is provided at 25 µL, 10mM.
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Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 [1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Calla M Olson, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170.
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