XMU-MP-3 |
| Catalog No.GC39825 |
XMU-MP-3은 10μM ATP의 존재하에서 BTK WT 및 BTK C481S 돌연변이에 대해 각각 10.7nM 및 17.0nM의 IC50을 갖는 강력한 비공유 BTK 억제제입니다. XMU-MP-3는 또한 apoptosis를 유도합니다.
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Cas No.: 2031152-08-4
Sample solution is provided at 25 µL, 10mM.
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XMU-MP-3 is a potent non-covalent BTK inhibitor with IC50s of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation in the presence of 10 μM ATP, respectively. XMU-MP-3 also induces apoptosis[1].
[1]. Fu Gui, et al. A Non-Covalent Inhibitor XMU-MP-3 Overrides Ibrutinib-Resistant Btk C481S Mutation in B-cell Malignancies. Br J Pharmacol. 2019 Dec;176(23):4491-4509.
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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