Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Research Areas
- ATM/ATR(28)
- Aurora Kinase(35)
- Cdc42(4)
- Cdc7(3)
- Chk(13)
- c-Myc(51)
- CRM1(10)
- Cyclin-Dependent Kinases(70)
- E1 enzyme(1)
- G-quadruplex(16)
- Haspin(6)
- HMTase(1)
- Kinesin(32)
- Ksp(4)
- Microtubule/Tubulin(300)
- Mps1(17)
- Mitotic(7)
- RAD51(13)
- ROCK(76)
- Rho(13)
- PERK(21)
- PLK(51)
- PTEN(7)
- Wee1(15)
- PAK(29)
- Arp2/3 Complex(10)
- Dynamin(18)
- ECM & Adhesion Molecules(53)
- Cholesterol Metabolism(10)
- Endomembrane System & Vesicular Trafficking(34)
- G1(50)
- G2/M(35)
- G2/S(16)
- Genotoxic Stress(22)
- Inositol Phosphates(65)
- Proteolysis(179)
- Cytoskeleton & Motor Proteins(71)
- Cellular Chaperones(14)
- Cyclin G-associated Kinase (GAK)(2)
- MARK(4)
- NEKs(9)
- ATF6(2)
- ClpP(6)
- Disulfidptosis(1)
- HMG Family(1)
- PDI(1)
- SWI/SNF Complex(7)
- VISTA(4)
- HOXA(1)
Products Related to Cell Cycle/Checkpoint(1536)
- GC11383CYT997 (Lexibulin)CAS: 917111-44-5Purity: >98.00%
CYT997 (Lexibulin) (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. CYT997 (Lexibulin) induces cell apoptosis and induces mitochondrial ROS generation in GC cells.
- GC13815Vinflunine TartrateCAS: 1201898-17-0Purity: >98.00%
Etanercept is an inhibitor of the inflammatory factor TNF-α and is mainly used for the clinical treatment of rheumatoid arthritis .
- GC14701Zoledronic AcidCAS: 118072-93-8Purity: >99.00%
Zoledronic Acid is a third-generation nitrogen-containing bisphosphonate bone resorption inhibitor.
- GC15377LEE011 succinateCAS: 1374639-75-4Purity: >99.50%
LEE011 succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
- GC15922LEE011 hydrochlorideCAS: 1211443-80-9Purity: >98.00%
LEE011 hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
- GC12515NMS-1286937CAS: 1034616-18-6Purity: >98.00%
NMS-1286937 is an orally active small-molecule compound. NMS-1286937 potently and selectively inhibits Polo-like kinase 1 (PLK1) activity with a half-maximal inhibitory concentration (IC 50 ) of 2nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC11383 | CYT997 (Lexibulin) | 917111-44-5 | >98.00% | |
CYT997 (Lexibulin) (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. CYT997 (Lexibulin) induces cell apoptosis and induces mitochondrial ROS generation in GC cells. | ||||
| GC12415 | Rigosertib | 592542-59-1 | >98.50% | |
PI3K/PLK1 inhibitor | ||||
| GC13423 | Y-39983 dihydrochloride | 173897-44-4 | >98.50% | |
ROCK family inhibitor | ||||
| GC13484 | Griseofulvin | 126-07-8 | >98.50% | |
Microtubule associated inhibitor | ||||
| GC13580 | Rigosertib sodium | 592542-60-4 | >98.50% | |
Non-ATP-competitive inhibitor of PLK1 | ||||
| GC13815 | Vinflunine Tartrate | 1201898-17-0 | >98.00% | |
Etanercept is an inhibitor of the inflammatory factor TNF-α and is mainly used for the clinical treatment of rheumatoid arthritis . | ||||
| GC14162 | ML167 | 1285702-20-6 | >98.50% | |
Clk4 inhibitor,highly selective | ||||
| GC14701 | Zoledronic Acid | 118072-93-8 | >99.00% | |
Zoledronic Acid is a third-generation nitrogen-containing bisphosphonate bone resorption inhibitor. | ||||
| GC14974 | AMG 925 | 1401033-86-0 | >98.00% | |
AMG 925 is an orally active dual FLT3 and CDK4 kinase inhibitor (IC 50 =1nM and 3nM). | ||||
| GC15377 | LEE011 succinate | 1374639-75-4 | >99.50% | |
LEE011 succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. | ||||
| GC15712 | Y-27632 | 146986-50-7 | >98.00% | |
A ROCK inhibitor,potent and selective | ||||
| GC15922 | LEE011 hydrochloride | 1211443-80-9 | >98.00% | |
LEE011 hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. | ||||
| GC16000 | WHI-P180 | 211555-08-7 | >99.50% | |
EGFR/Janus Kinase 3 inhibitor | ||||
| GC16273 | Dolastatin 10 | 110417-88-4 | >98.50% | |
Antitumor agent | ||||
| GC17067 | LDC000067 | 1073485-20-7 | >98.50% | |
CDK9 inhibitor, novel and highly specific | ||||
| GC17388 | K-Ras(G12C) inhibitor 6 | 2060530-16-5 | >98.00% | |
K-Ras (G12C) inhibitor | ||||
| GC17400 | R547 | 741713-40-6 | >99.50% | |
CDK1/2/4 inhibitor,ATP-competitive | ||||
| GC10722 | SR-3677 | 1072959-67-1 | >99.50% | |
Rho Kinase (ROCK-II) inhibitor | ||||
| GC10442 | MK-8745 | 885325-71-3 | >99.00% | |
Aurora A inhibitor,potent and selective | ||||
| GC12515 | NMS-1286937 | 1034616-18-6 | >98.00% | |
NMS-1286937 is an orally active small-molecule compound. NMS-1286937 potently and selectively inhibits Polo-like kinase 1 (PLK1) activity with a half-maximal inhibitory concentration (IC 50 ) of 2nM. | ||||
| GC12642 | THZ1 Hydrochloride | 1604810-83-4 | >98.00% | |
CDK7 inhibitor | ||||
| GC13869 | Fasudil | 103745-39-7 | >98.00% | |
Fasudil (HA-1077; AT877) is a non-specific RhoA/ROCK inhibitor with a K i of 0.33μM and an IC 50 of 0.158μM for ROCK1, and IC 50 of 4.58μM, 12.30μM, and 1.650μM for ROCK2, PKA, PKC, and PKG, respectively. | ||||
| GC14735 | Poloxime | 17302-61-3 | >98.00% | |
polo-like kinase 1 （PLK) analogue | ||||
| GC15914 | CDK7-IN-1 | 1604810-84-5 | - | |
potent and selective CDK7 inhibitor | ||||