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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> RAD51

RAD51

RAD51 is a protein that contributed to homologous recombination and DSB (DNA double-strand break) repair in the DNA damage response pathway. It is associated with genome instablility and tumorgenesis.

Products for  RAD51

  1. Cat.No. Product Name Information
  2. GC16391 Amuvatinib (MP-470, HPK 56)

    HPK56, MP470

     A multi-targeted RTK inhibitor Amuvatinib (MP-470, HPK 56) Chemical Structure
  3. GC33362 Amuvatinib hydrochloride (MP470 hydrochloride)

    MP470 hydrochloride; HPK 56 hydrochloride

     Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair. Antineoplastic activity. Amuvatinib hydrochloride (MP470 hydrochloride) Chemical Structure
  4. GC62128 Bractoppin Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain with an IC50 value of 74nM. Bractoppin Chemical Structure
  5. GC65935 CAM833

    CAM833, a sub-micromolar chemical inhibitor of the regulatory protein-protein interaction between the RAD51 recombinase and the BRC repeat motifs of the tumor suppressor BRCA2.

     CAM833 Chemical Structure
  6. GC32912 IBR2 IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis. IBR2 Chemical Structure
  7. GC19306 RAD51 Inhibitor B02

    B02

     RAD51 Inhibitor B02 is a specific inhibitor of the human RAD51 recombinase (with an IC50 value of 27.4μM), and it has no inhibitory effect on the homologous RecA in Escherichia coli (with an IC50 > 250μM). RAD51 Inhibitor B02 Chemical Structure
  8. GC63165 RAD51-IN-1 RAD51-IN-1, a derivative of ?B02, is a potent inhibitor of RAD51. RAD51-IN-1 can be used for cancer research. RAD51-IN-1 Chemical Structure
  9. GC65383 RAD51-IN-2 RAD51-IN-2 (compound example 67A) is a RAD51 inhibitor extracted from patent WO2019/051465A1. RAD51-IN-2 Chemical Structure
  10. GC68416 RAD51-IN-3 RAD51-IN-3 Chemical Structure
  11. GC67888 RAD51-IN-5 RAD51-IN-5 Chemical Structure
  12. GC18140 RI-1 RI-1 is a RAD51 protein inhibitor, with IC50 values ranging from 5 to 30μM. RI-1 Chemical Structure
  13. GC12752 RI-2 Optimized reversible RAD51 inhibitor RI-2 Chemical Structure
  14. GC16265 RS-1 RAD51 activator RS-1 Chemical Structure

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