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Aurora Kinase

Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.

  1. Cat.No. Product Name Information
  2. GC13198 AMG-900 Aurora kinase inhibitor
  3. GC17284 Anacardic acid HAT inhibitor
  4. GC10638 AT9283 Aurora kinase/JAK inhibitor
  5. GC13332 Aurora A Inhibitor I Aurora A inhibitor
  6. GC33379 Aurora B inhibitor 1
  7. GC38441 Aurora Kinase Inhibitor 3
  8. GC14709 AZD1152 Aurora B kinase inhibitor,highly potent and selective
  9. GC14955 Barasertib (AZD1152-HQPA)

    Aurora Kinase B inhibitor, Potent and selective

  10. GC17828 BI-847325 dual inhibitor of MEK and Aurora kinases
  11. GC11310 CCT129202

    Aurora kinase inhibitor,ATP-competitive and potent

  12. GC14566 CCT137690 Aurora A/B/C inhibitor
  13. GC19092 CCT241736 CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM).
  14. GC15106 CYC116 Potent Aurora A/B inhibitor
  15. GC15217 Danusertib (PHA-739358)

    Pan-aurora kinase inhibitor

  16. GC16519 ENMD-2076 Selective Aurora A/Flt3 inhibitor
  17. GC12145 ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor
  18. GC10008 GSK1070916 Aurora B/C inhibitor
  19. GC17196 Hesperadin Aurora B kinase inhibitor
  20. GC34159 Ilorasertib (ABT-348)
  21. GC38519 Ilorasertib hydrochloride

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