DNA Damage/DNA Repair

STD1T is a deubiquitinase USP2a inhibitor with an IC50 of 3.3 μM in Ub-AMC Assay.

XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34?nM. XL177A elicits cancer cell killing through a p53-dependent mechanism.

2’-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.

2’-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.

2’-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.

5’-O-DMT-3’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.

DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides

Uridine triphosphate 13C9,15N2 (UTP 13C9,15N2) sodium is a labeled Uridine triphosphate sodium.

5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside.

ART558 is a potent and selective low-molecular-weight allosteric inhibitor of DNA polymerase Polθ, with a molecular weight (MW) in the nanomolar range and an IC50 of 7.9 nM.

hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of 900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM).

5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.

5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.

5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.

5’-O-DMT-N4-Bz-5-Me-dC is a modified nucleoside.

5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.

5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.

5’-O-TBDMS-dG is a modified nucleoside.

5’-O-TBDMS-dT is a nucleoside with protective and modification effects.

CDK7-IN-3 (CDK7-IN-3) is an orally active, highly selective, noncovalent CDK7 inhibitor with a KD of 0.065 nM. CDK7-IN-3 shows poor inhibition on CDK2 (Ki=2600 nM), CDK9 (Ki=960 nM), CDK12 (Ki=870 nM). CDK7-IN-3 induces apoptosis in tumor cells and has antitumor activity.

EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor.

rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A?inhibitor with activity less than Zotatifin.

bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM.