The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) is an enzyme that in humans is encoded by the ERN1 gene. IRE1 is an endoplasmic reticulum (ER) transmembrane sensor that activates UPR to maintain ER and cellular function. While mammalian IRE1 promotes cell survive, it can initiate apoptosis via decay of anti-apoptotic microRNAs.
IRE1 activation is initiated by homotypic interactions of the stress-sensing lumenal domain favoring transautophosphorylation of the kinase-extension nuclease (KEN) domain on the cytoplasmic side of the ER membrane.
IRE1/XBP-1 has been shown to regulate a variety of genes in various cell types in response to ER stress, mostly related to ER function and the secretory pathway, although the target genes vary depending on the cell type and nature of the stress stimuli.
Products for IRE1
- Cat.No. Product Name Information
- GC34384 3,6-DMAD hydrochloride
IRE1 Rnase inhibitor, potent and non-toxic
- GC17139 APY29 IRE1α inhibitor
- GC33406 B I09
- GC32857 GSK2850163
- GC34205 GSK2850163 hydrochloride
- GC19212 KIRA6 KIRA6 allosterically inhibits IRE1α RNase kinase activity with an IC50 of 0.6 uM.
- GC31879 Kira8
- GC18303 MKC-3946 MKC-3946 is an inhibitor of inositol-requiring enzyme 1α (IRE1α).
- GC32889 MKC8866 (IRE-1α inhibitor 1)
- GC32910 MKC9989
- GC34111 NSC95682 (6-Bromo-2-hydroxy-3-methoxybenzaldehyde)
- GC12937 STF 083010 IRE1α endonuclease inhibitor
- GC17651 Sunitinib RTK inhibitor
- GC14683 Sunitinib malate VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor
Adenosine analog,antitumor antibiotic