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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> DNA Alkylating

DNA Alkylating

DNA alkylating is the transfer of alkyl groups to particular bases, resulting in alkylation products such as O2‐alkylthymine and O6‐methylguanine that lead to DNA mutations.

Products for  DNA Alkylating

  1. Cat.No. Product Name Information
  2. GC49470 1-Ethyl-1-nitrosourea (hydrate)

    ENU, Ethylnitrosourea, N-Ethyl-N-nitrosourea, N-Nitroso-N-ethylurea

     A DNA alkylating agent 1-Ethyl-1-nitrosourea (hydrate) Chemical Structure
  3. GC52129 3-Amino-5-hydroxybenzoic Acid

    AHBA

     3-Amino-5-hydroxybenzoic Acid Chemical Structure
  4. GC90549 5-Aminoimidazole-4-carboxamide (hydrate)

    A synthetic precursor

     5-Aminoimidazole-4-carboxamide (hydrate) Chemical Structure
  5. GC14564 Altretamine

    2,4,6-Tris(dimethylamino)-1,3,5-triazine, Hexamethylmelamine, HMM, NSC 13875

     Antineoplastic agent Altretamine Chemical Structure
  6. GC46914 Bendamustine-d4 (hydrochloride) A neuropeptide with diverse biological activities Bendamustine-d4 (hydrochloride) Chemical Structure
  7. GC13671 Busulfan

    Busulphan, Mielosan, Milecitan, Myeloleukon, Mylecytan, Myleran, NCI C01592, NSC 750

     DNA alkylating agent Busulfan Chemical Structure
  8. GC15793 Carmustine

    BCNU, bis-Chloroethylnitrosourea, NSC 409962

     cell-cycle phase nonspecific alkylating antineoplastic agent Carmustine Chemical Structure
  9. GC91899 Carmustine-d8

    BCNU-d8; bis-Chloroethylnitrosourea-d8

     Carmustine-d8 is intended for use as an internal standard for the quantification of carmustine by GC- or LC-MS. Carmustine-d8 Chemical Structure
  10. GC47078 Chlorambucil-d8

    CB-1348-d8; WR-139013-d8

     A neuropeptide with diverse biological activities Chlorambucil-d8 Chemical Structure
  11. GC91297 Cholesterol-Doxorubicin

    A prodrug form of doxorubicin

     Cholesterol-Doxorubicin Chemical Structure
  12. GC90657 COMC

    An anticancer agent

     COMC Chemical Structure
  13. GC47167 Dacarbazine-d6 An internal standard for the quantification of dacarbazine Dacarbazine-d6 Chemical Structure
  14. GC18100 Illudin S

    Lampterol,NSC 400979,NSC 626369

     potent antitumor sesquiterpene Illudin S Chemical Structure
  15. GC41384 K-TMZ K-TMZ is a DNA alkylating agent. K-TMZ Chemical Structure
  16. GC17865 Lomustine

    CCNU, NCI C04740, NSC 79037

     Antineoplastic drug Lomustine Chemical Structure
  17. GC44243 Monohydroxy Melphalan (hydrochloride)

    Hydroxymelphalan

     Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan. Monohydroxy Melphalan (hydrochloride) Chemical Structure
  18. GC44251 MTIC

    NSC 407347

    MTIC is a DNA alkylating agent, an active metabolite of dacarbazine, and an active degradation product of temozolomide.

     MTIC Chemical Structure
  19. GC44348 N-desmethyl Bendamustine

    nor-Bendamustine

     N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine. N-desmethyl Bendamustine Chemical Structure
  20. GC14762 Palifosfamide

    Isophosphoramide Mustard, NSC 297900

     An active metabolite of ifosfamide Palifosfamide Chemical Structure
  21. GC13667 Temozolomide

    CCRG 81045, MB 39831, Methazolastone, NSC 362856, Temodal, TMZ

     Temozolomide is an oral activity alkylating agent that induces the formation of O6-methylguanine in DNA, which mispairs with thymine during the following cycle of DNA replication, leading to activation of the apoptotic pathways, Temozolomide could crosses the blood-brain barrier and is indicated for malignant gliomas and metastatic melanomas. Temozolomide Chemical Structure
  22. GC52076 Temozolomide Acid

    Temozolomide 8-Carboxylic Acid, TMZA

     Temozolomide Acid is a carboxylic acid derivative of Temozolomide. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide Acid has an activity similar to the parent compound Temozolomide with the same anticancer activity. Temozolomide Acid Chemical Structure
  23. GC16158 Thio-TEPA

    NCI C01649, NSC 6396, Triethylenethiophosphoramide

     alkylating agent used to treat cancer Thio-TEPA Chemical Structure
  24. GC15043 Trioxsalen

    NSC 71047,4,5’,8-Trimethylpsoralen,Trisoralen

     intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light Trioxsalen Chemical Structure

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