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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> Casein Kinase

Casein Kinase

Casein Kinases (CKs) are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types.

Targets for  Casein Kinase

Products for  Casein Kinase

  1. Cat.No. Product Name Information
  2. GC62735 (E/Z)-GO289 (E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function. (E/Z)-GO289 Chemical Structure
  3. GC46351 (S)-CR8 An inhibitor of cyclin-dependent kinases (S)-CR8 Chemical Structure
  4. GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride Chemical Structure
  5. GC64638 ALV1 ALV1 is a potent Ikaros and Helios degrader. ALV1 Chemical Structure
  6. GC14899 AMG 548

    P38α inhibitor,potent and selective

     AMG 548 Chemical Structure
  7. GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride Chemical Structure
  8. GC62880 BTX161 BTX161, a Thalidomide analog, is a potent CKIα degrader. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2. BTX161 Chemical Structure
  9. GC66033 Casein kinase 1δ-IN-1 Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research. Casein kinase 1δ-IN-1 Chemical Structure
  10. GC67775 Casein kinase 1δ-IN-3 Casein kinase 1δ-IN-3 Chemical Structure
  11. GC71277 Casein kinase 1δ-IN-6 Casein kinase 1δ-IN-6 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 23 nM. Casein kinase 1δ-IN-6 Chemical Structure
  12. GC72207 Casein Kinase 2 Substrate Peptide Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide. Casein Kinase 2 Substrate Peptide Chemical Structure
  13. GC30276 Casein Kinase II Inhibitor IV

    Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC50 of 9 nM.

     Casein Kinase II Inhibitor IV Chemical Structure
  14. GC34356 Casein Kinase II Inhibitor IV Hydrochloride Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocytedifferentiation. Casein Kinase II Inhibitor IV Hydrochloride Chemical Structure
  15. GC62442 Casein Kinase inhibitor A51 Casein Kinase inhibitor A51 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities. Casein Kinase inhibitor A51 Chemical Structure
  16. GC63463 Casein Kinase inhibitor A86 Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities. Casein Kinase inhibitor A86 Chemical Structure
  17. GC40515 CAY10577 Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase involved in many signal transduction pathways. CAY10577 Chemical Structure
  18. GC43177 CAY10578 Casein Kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CAY10578 Chemical Structure
  19. GC34536 CK1-IN-1 CK1-IN-1 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively. CK1-IN-1 Chemical Structure
  20. GC73500 CK1-IN-2

    CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with an IC50 values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively.

     CK1-IN-2 Chemical Structure
  21. GC62337 CK2 inhibitor 2 CK2 inhibitor 2 is a potent, selective and orally active inhibitor of CK2, with an IC50 of 0.66 nM. CK2 inhibitor 2 shows high selectivity for Clk2 (IC50=32.69 nM)/CK2. CK2 inhibitor 2 exhibits favorable antiproliferative and antitumor activity. CK2 inhibitor 2 Chemical Structure
  22. GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8 CK2/ERK8-IN-1 Chemical Structure
  23. GC38755 CKI-7 CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases. CKI-7 Chemical Structure
  24. GC13037 CX-4945 (Silmitasertib)

    CX 4945;CX4945

     CX-4945 (Silmitasertib) (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 (Silmitasertib) Chemical Structure
  25. GC11325 CX-4945 sodium salt

    CX-4945 sodium salt

     CX-4945 sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 sodium salt Chemical Structure
  26. GC13202 D4476

    Casein Kinase I Inhibitor

     Inhibitor of CK1 and ALK5 D4476 Chemical Structure
  27. GC73741 DEG-77 DEG-77, a PROTAC based IKZF2 and CK1α degrader, possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h). DEG-77 Chemical Structure
  28. GC17837 DMAT

    Casein Kinase II Inhibitor II, 2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole

     A cell-permeable inhibitor of CK2 DMAT Chemical Structure
  29. GC15548 Ellagic acid

    Gallogen, Lagistase, TBBD

     Casein kinase 2 (CK2) inhibitor Ellagic acid Chemical Structure
  30. GC16044 Emodin

    Archin, Frangulic Acid, NSC 408120, NSC 622947, Schuttgelb

     Natural CK2 inhibitor and ER agonist Emodin Chemical Structure
  31. GC43618 Epiblastin A

    Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms α, δ, and ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively).

     Epiblastin A Chemical Structure
  32. GC64005 FPFT-2216 FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 Chemical Structure
  33. GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Hematein Chemical Structure
  34. GC14503 IC261

    SU5607

     CK1 inhibitor IC261 Chemical Structure
  35. GC52175 IQA

    CGP 029482

     IQA Chemical Structure
  36. GC16454 IWP-2

    IWP 2

     IWP-2 is a specific inhibitor of Porcupine enzyme in the Wnt signaling pathway, with an IC50 value of 27 nM. IWP-2 Chemical Structure
  37. GC17466 LH846 Casein kinases inhibitor LH846 Chemical Structure
  38. GC34650 Longdaysin

    Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of? 5.6 ?M, 8.8 ?M, 29 ?M, and 52 ?M, respectively.

     Longdaysin Chemical Structure
  39. GC50009 LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases LY 294002 hydrochloride Chemical Structure
  40. GC36708 NCC007 NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 Chemical Structure
  41. GC73707 ON 108600 ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 Chemical Structure
  42. GC69633 Orobol

    Orobol is a major soy isoflavone with various pharmacological activities, including anti-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K subtypes (for PI3K α/β/γ/K/δ, IC50=3.46-5.27 μM).

     Orobol Chemical Structure
  43. GC44612 PF-4800567 PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. PF-4800567 Chemical Structure
  44. GC36885 PF-5006739 PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 Chemical Structure
  45. GC10556 PF-670462 An inhibitor of the CK1 isoforms CK1ε and CK1δ PF-670462 Chemical Structure
  46. GC38578 PI-828 A PI3K inhibitor PI-828 Chemical Structure
  47. GC64382 SGC-CK2-1 SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 Chemical Structure
  48. GC73870 SJ3149 SJ3149 is a selective and potent in vitro and in vivo degrader of CK1α protein with broad antiproliferative activity. SJ3149 Chemical Structure
  49. GC19336 SR-3029 SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases. SR-3029 Chemical Structure
  50. GC72856 SRPIN803 SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 Chemical Structure
  51. GC13825 TA 01

    CK1ε, CK1δ,and p38α inhibitor

     TA 01 Chemical Structure
  52. GC12181 TBB

    NSC 231634, Tetrabromobenzotriazole

     An inhibitor of CK2 TBB Chemical Structure
  53. GC64131 TMX-4116 TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma. TMX-4116 Chemical Structure
  54. GC10649 TTP 22

    TTP22;TTP-22

     A CK2 inhibitor TTP 22 Chemical Structure

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