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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> LIM Kinase (LIMK)

LIM Kinase (LIMK)

LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases. The LIMK family consists of two homologues, LIMK1 and LIMK2, which differ from one another in expression profile, intercellular localization, and function. The main substrate of LIMK is cofilin, a member of the actin-depolymerizing factor (ADF) protein family. When phosphorylated by LIMK, cofilin is inactive. LIMKs play a contributory role in several neurodevelopmental disorders and in cancer growth and metastasis.

LIM domain kinases (LIMK1 and 2) are substrate for Cdc42/Rac-PAK, and modulate actin dynamics by phosphorylating cofilin at serine-3. This modification inactivates cofilin’s actin severing and depolymerizing activity. LIMKs also translocate into the nucleus and regulate cell cycle progression. LIMKs are potential therapeutic targets for NF2 and other merlin-deficient tumors.

Targets for  LIM Kinase (LIMK)

Products for  LIM Kinase (LIMK)

  1. Cat.No. Product Name Information
  2. GC19076 BMS-3 BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. BMS-3 Chemical Structure
  3. GC50404 CRT 0105950 Potent LIMK1/2 inhibitor CRT 0105950 Chemical Structure
  4. GC68913 Curcolonol

    Curcolonol is a furanoid sesquiterpene that can be isolated from several herbs. It has inhibitory activity against LIM kinase 1 and can be used in breast cancer research.

     Curcolonol Chemical Structure
  5. GC71011 DB0614 DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 Chemical Structure
  6. GC15511 LIMKi 3

    LIM Kinase Inhibitor I, LIMKi 3

     LIMKi 3 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. LIMKi 3 Chemical Structure
  7. GC44094 LX7101 (hydrochloride) LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively. LX7101 (hydrochloride) Chemical Structure
  8. GC65207 R-10015 R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1. R-10015 Chemical Structure
  9. GC62675 SM1-71 SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. SM1-71 Chemical Structure
  10. GC50219 SR 7826 Potent and selective LIMK inhibitor; antitumor SR 7826 Chemical Structure
  11. GC16355 T 5601640

    T56-LIMKi, T56-LIM Kinase Inhibito

     T 5601640 is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. T 5601640 Chemical Structure
  12. GC38860 TH-257 An inhibitor of LIMK1 and LIMK2 TH-257 Chemical Structure
  13. GC73353 TH470 TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research. TH470 Chemical Structure

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