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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> LIM Kinase (LIMK)

LIM Kinase (LIMK)

LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases. The LIMK family consists of two homologues, LIMK1 and LIMK2, which differ from one another in expression profile, intercellular localization, and function. The main substrate of LIMK is cofilin, a member of the actin-depolymerizing factor (ADF) protein family. When phosphorylated by LIMK, cofilin is inactive. LIMKs play a contributory role in several neurodevelopmental disorders and in cancer growth and metastasis.

LIM domain kinases (LIMK1 and 2) are substrate for Cdc42/Rac-PAK, and modulate actin dynamics by phosphorylating cofilin at serine-3. This modification inactivates cofilin’s actin severing and depolymerizing activity. LIMKs also translocate into the nucleus and regulate cell cycle progression. LIMKs are potential therapeutic targets for NF2 and other merlin-deficient tumors.

Targets for  LIM Kinase (LIMK)

Products for  LIM Kinase (LIMK)

  1. Cat.No. Product Name Information
  2. GC19076 BMS-3 BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. BMS-3 Chemical Structure
  3. GC50404 CRT 0105950 Potent LIMK1/2 inhibitor CRT 0105950 Chemical Structure
  4. GC15511 LIMKi 3 LIMKi 3 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. LIMKi 3 Chemical Structure
  5. GC65207 R-10015 R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1. R-10015 Chemical Structure
  6. GC62675 SM1-71 SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. SM1-71 Chemical Structure
  7. GC50219 SR 7826 Potent and selective LIMK inhibitor; antitumor SR 7826 Chemical Structure
  8. GC16355 T 5601640 T 5601640 is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. T 5601640 Chemical Structure
  9. GC38860 TH-257 An inhibitor of LIMK1 and LIMK2 TH-257 Chemical Structure

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