1-Alaninechlamydocin |
| Catalog No.GC41984 |
La 1-alanina clamidocina, un tetrapéptido cÍclico, es un potente inhibidor de HDAC (IC50 = 6,4 nM). La 1-alaninaclamidocina induce la detenciÓn del ciclo celular G2/M y la apoptosis en células MIA PaCa-2.
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Cas No.: 141446-96-0
Sample solution is provided at 25 µL, 10mM.
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1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).
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