1-Alaninechlamydocin |
| カタログ番号GC41984 |
環状テトラペプチドである 1-アラニンケラミドシンは、強力な HDAC 阻害剤です (IC50=6.4 nM)。 1-アラニンケラミドシンは、MIA PaCa-2 細胞で G2/M 細胞周期の停止とアポトーシスを誘導します。
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Cas No.: 141446-96-0
Sample solution is provided at 25 µL, 10mM.
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1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).
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