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1-Alaninechlamydocin

Catalog No.GC41984

La 1-alaninechlamydocine, un tétrapeptide cyclique, est un puissant inhibiteur d'HDAC (IC50 = 6,4 nM). La 1-alaninechlamydocine induit l'arrêt du cycle cellulaire G2/M et l'apoptose dans les cellules MIA PaCa-2.

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1-Alaninechlamydocin Chemical Structure

Cas No.: 141446-96-0

Taille Prix Stock Qté
500μg
272,00 $US
En stock
2.5mg
1 227,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).

Chemical Properties

Cas No. 141446-96-0 SDF
Canonical SMILES O=C(N[C@@H](CCCCCC([C@@H]1CO1)=O)C(N[C@H]2C)=O)[C@]3([H])N(CCC3)C([C@H](CC4=CC=CC=C4)NC2=O)=O
Formula C27H36N4O6 M.Wt 512.6
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.9508 mL 9.7542 mL 19.5084 mL
5 mM 0.3902 mL 1.9508 mL 3.9017 mL
10 mM 0.1951 mL 0.9754 mL 1.9508 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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