3-Hydroxy Midostaurin (Synonyms: CGP52421) |
Catalog No.GC39689 |
La 3-hidroximidostaurina (CGP 52421), un metabolito de PKC412, inhibe eficazmente la autofosforilaciÓn de tirosina quinasa-3 (FLT3) similar a FMS con IC50 de aproximadamente 132 nM y 9,8 μM en medio de cultivo y plasma, respectivamente. La 3-hidroximidostaurina es menos selectiva pero mÁs citotÓxica que PKC412.
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Cas No.: 179237-49-1
Sample solution is provided at 25 µL, 10mM.
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.
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