7,3',4'-Trihydroxyflavone (Synonyms: 3’,4’,7-Trihydroxyflavone, 5-Deoxyluteolin) |
Catalog No.GC46080 |
7,3',4'-La trihidroxiflavona es un compuesto de aglicÓn flavonoide aislado de las vainas de habas.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2150-11-0
Sample solution is provided at 25 µL, 10mM.
7,3',4'-Trihydroxyflavone is a flavonoid that has been found in A. julibrissin bark and has diverse biological activities.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 μM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 μM).1 7,3',4'-Trihydroxyflavone inhibits COX-1 (IC50 = 36.7 μM).2 It is active against M. tuberculosis (MIC = 50 μg/ml).3 It decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, cathepsin K1 V-ATPase V0 subunit d2 (Atp6v0d2), and dendritic cell specific transmembrane protein (Dcstamp) in and inhibits RANKL-induced osteoclastic differentiation of mouse bone marrow-derived macrophages (BMDMs).4
|1. Jung, M.J., Chung, H.Y., Kang, S.S., et al. Antioxidant activity from the stem bark of Albizzia julibrissin. Arch. Pharm. Res. 26(6), 458-462 (2003).|2. Selvam, C., Jachak, S.M., and Bhutani, K.K. Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn. Phytother. Res. 18(7), 582-584 (2004).|3. Chokchaisiri, R., Suaisom, C., Sriphota, S., et al. Bioactive flavonoids of the flowers of Butea monosperma. Chem. Pharm. Bull. (Tokyo) 57(4), 428-432 (2009).|4. Kang, J.H., Lee, J., Moon, M., et al. 3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. Pharmazie 70(10), 661-667 (2015).
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