7,3',4'-Trihydroxyflavone (Synonyms: 3’,4’,7-Trihydroxyflavone, 5-Deoxyluteolin) |
| カタログ番号GC46080 |
7,3',4&7#39;-トリヒドロキシフラボンは、ソラマメのさやから分離されたフラボノイド アグリコン化合物です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2150-11-0
Sample solution is provided at 25 µL, 10mM.
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7,3',4'-Trihydroxyflavone is a flavonoid that has been found in A. julibrissin bark and has diverse biological activities.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 μM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 μM).1 7,3',4'-Trihydroxyflavone inhibits COX-1 (IC50 = 36.7 μM).2 It is active against M. tuberculosis (MIC = 50 μg/ml).3 It decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, cathepsin K1 V-ATPase V0 subunit d2 (Atp6v0d2), and dendritic cell specific transmembrane protein (Dcstamp) in and inhibits RANKL-induced osteoclastic differentiation of mouse bone marrow-derived macrophages (BMDMs).4
|1. Jung, M.J., Chung, H.Y., Kang, S.S., et al. Antioxidant activity from the stem bark of Albizzia julibrissin. Arch. Pharm. Res. 26(6), 458-462 (2003).|2. Selvam, C., Jachak, S.M., and Bhutani, K.K. Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn. Phytother. Res. 18(7), 582-584 (2004).|3. Chokchaisiri, R., Suaisom, C., Sriphota, S., et al. Bioactive flavonoids of the flowers of Butea monosperma. Chem. Pharm. Bull. (Tokyo) 57(4), 428-432 (2009).|4. Kang, J.H., Lee, J., Moon, M., et al. 3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. Pharmazie 70(10), 661-667 (2015).
| Cas No. | 2150-11-0 | SDF | |
| 同義語 | 3’,4’,7-Trihydroxyflavone, 5-Deoxyluteolin | ||
| Canonical SMILES | O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=C1C=CC(O)=C3 | ||
| Formula | C15H10O5 | M.Wt | 270.2 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 5 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.701 mL | 18.5048 mL | 37.0096 mL |
| 5 mM | 0.7402 mL | 3.701 mL | 7.4019 mL |
| 10 mM | 0.3701 mL | 1.8505 mL | 3.701 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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