AA 147 |
| Catalog No.GC50566 |
AA 147 es un regulador de la proteostasis del retículo endoplásmico (RE).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 393121-74-9
Sample solution is provided at 25 µL, 10mM.
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Endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).
Plate et al (2016) Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 5 e15550 PMID:27435961
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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