Enniatin A1 |
Catalog No.GC43610
One-Click Copy Product Info
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Fusarium mycotoxins에서 분리된 Enniatin A1은 교대로 D-α-hydroxyisovaleric acid와 N-methyl-L-amino acid로 구성된 고리형 hexadepsipeptide입니다. 엔니아틴 A1은 세포 사멸을 유도하고 ERK 신호 전달 경로를 방해하여 항암 특성을 가지고 있습니다. Enniaatin A1은 쥐 간 마이크로솜에서 49μM의 IC50으로 ACAT를 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4530-21-6
Sample solution is provided at 25 µL, 10mM.
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Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Many function as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin A1 is one of four major analogs in the enniatin complex . Its ionophoric activity has been described. Additionally, enniatin A1 has been found to induce apoptosis in cancer cells (EC50 = 5 µM in H4IIE rat hepatoma cells), decreasing the activation of the cell proliferation kinase, ERK (p44/p42) and inhibiting TNF-α-induced NF-κB activation.
| Cas No. | 4530-21-6 | SDF | |
| Canonical SMILES | C[C@@H](CC)[C@]([H])(N(C)C([C@@H](C(C)C)OC([C@H]([C@H](CC)C)N(C)C1=O)=O)=O)C(O[C@]([H])(C(C)C)C(N(C)[C@@H](C(C)C)C(O[C@@H]1C(C)C)=O)=O)=O | ||
| Formula | C35H61N3O9 | M.Wt | 667.9 |
| Solubility | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.4972 mL | 7.4862 mL | 14.9723 mL |
| 5 mM | 299.4 μL | 1.4972 mL | 2.9945 mL |
| 10 mM | 149.7 μL | 748.6 μL | 1.4972 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A Powder
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)