DK419 |
| Catalog No.GC35873 |
DK419 es un inhibidor de la seÑalizaciÓn de Wnt/β-catenina potente y activo por vÍa oral, con una IC50 de 0,19 μM. DK419 reduce los niveles de proteÍna de Axin2, β-catenina, c-Myc, Cyclin D1 y Survivin e induce la producciÓn de pAMPK.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2102672-22-8
Sample solution is provided at 25 µL, 10mM.
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DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1]. Wnt/β-catenin[1]
[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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