Lenalidomide-Br |
| Catalog No.GC38579 |
Lenalidomida-Br (Compuesto 41) es un anÁlogo del ligando de cereblon (CRBN) Lenalidomida para la ubiquitina ligasa E3, y se utiliza en el reclutamiento de la proteÍna CRBN. La lenalidomida-Br se puede conectar al ligando de la proteÍna mediante un conector para formar PROTAC, como el degradador SD-36 de PROTAC STAT3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093387-36-9
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-Br (Compound 41) is the Lenalidomide-based ligand. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. [2]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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